Heathcare Treasure

Cancer remains one of the most challenging diseases to treat, but advancements in medical science are providing hope for better outcomes. Among the latest developments, TROP-2 inhibitors have emerged as a promising class of therapeutics, offering new possibilities for cancer patients. These inhibitors target TROP-2, a cell surface protein overexpressed in various cancers, making them a focal point in oncology research. TRODELVY: First FDA-approved Anti-TROP-2 ADC One of the most notable achievements in TROP-2 inhibitor research is the development of TRODELVY , the first FDA-approved antibody-drug conjugate (ADC) targeting TROP-2. TRODELVY has shown remarkable efficacy in treating metastatic triple-negative breast cancer (mTNBC) and metastatic urothelial cancer, offering new hope for patients with these aggressive malignancies. Its approval marked a significant milestone in cancer therapy, demonstrating the potential of TROP-2 inhibitors as a novel treatment approach. Promising TROP-2

  The ENHERTU Effect: A Closer Look at the Dynamic Duo Daiichi Sankyo and AstraZeneca Taking on HER2-mutant NSCLC Lung cancer remains one of the most challenging and prevalent forms of cancer. Within this landscape, innovative treatments are offering new hope. One such breakthrough is the collaboration between Daiichi Sankyo and AstraZeneca, which brings forth ENHERTU, an Antibody-Drug Conjugate (ADC). ENHERTU is making strides in targeting HER2-mutant Non-Small Cell Lung Cancer (NSCLC), a rare and challenging subset of the disease. The ENHERTU partnership aims to address this unmet medical need with a highly targeted approach. Dato-DXd vs. TRODELVY: The Battle of ADC Targeting TROP2 As the world of ADCs expands, another remarkable battle is brewing between Daiichi Sankyo's Dato-DXd and TRODELVY in their quest to target TROP2. TROP2, also known as CEACAM5, is an antigen overexpressed in various cancers, including endometrial cancer. Both ADCs hold the potential to transform the

Antibody-drug conjugates have emerged as a promising class of therapeutics in the field of oncology. By combining the specificity of monoclonal antibodies with the cytotoxic potency of chemotherapeutic drugs, Antibody-drug conjugates offer a targeted approach to cancer treatment. In this blog, we will explore the current and future landscape of Antibody-drug conjugates in oncology, including tumor markers and antibodies used in Antibody-drug conjugates, the existing marketed Antibody-drug conjugates, novel and emerging Antibody-drug conjugates in the pipeline, and the promising future of this transformative therapy. Tumor Markers and Antibodies in Antibody-drug conjugates: Antibody-drug conjugates utilize tumor-specific antigens as targets for delivering potent cytotoxic payloads directly to cancer cells. Commonly targeted tumor markers include HER2, CD30, and Trop-2, among others. Monoclonal antibodies are designed to recognize these markers and bind to them with high specificity. Th