Heathcare Treasure

IgA nephropathy (IgAN) , also known as Berger’s disease, is a chronic kidney disease characterized by the deposition of immunoglobulin A (IgA) in the glomeruli, leading to progressive kidney damage. It often presents with hematuria, proteinuria, and sometimes hypertension, ultimately increasing the risk of end-stage renal disease (ESRD). Despite its prevalence, effective targeted therapies for IgAN remain limited, driving research and development in this domain. IgA nephropathy Epidemiology Overview Globally, IgAN is a leading cause of primary glomerulonephritis, with significant regional variability in its incidence and prevalence. In the seven major markets (7MM), including the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan, the prevalence of IgAN is estimated to be approximately 5 cases per 100,000 population in 2023. Japan reports the highest prevalence due to increased screening and diagnosis. In contrast, lower detection rates in Western co...