Overcoming Delivery Obstacles in Acute Ocular Pain Treatment: A Technological Approach



One of the most frequent medical complaints in emergency clinics is ocular pain. Eye pain caused by debilitating eye disorders and post-ocular surgery affects the majority of the older population. Acute and chronic eye pain can be generally categorised; chronic eye pain is defined as lasting more than three months. Furthermore, the primary source of acute ocular pain is nociceptive pain.

Traditional acute ocular pain treatment options with significant unmet needs

Topical anesthetics, corticosteroids, ointments, gels, or drops are available as treatments for acute ocular pain. Yet, it has proven difficult for doctors to directly prescribe or dispense these medicines to patients due to their relationship with side effects and other drawbacks. Despite being effective, topical anesthetics frequently cause permanent corneal blindness. In addition, the frequent application of eye drops, the short contact duration, and the likelihood that the acute ocular pain medication will reach the target site are three main issues with the present acute ocular pain treatment.

Are we managing the pain efficiently?

In the past ten years, we have made significant strides in our understanding of neurophysiology, which has improved the methods for treating acute ocular pain The US FDA recently approved treatments like DEXTENZA, INVELTYS, and LOTEMAX SM to treat ocular inflammation and pain after ophthalmic surgery and cataract surgery to assist lessen the discomfort.

Novel drug delivery systems enhancing ocular residence time and bioavailability

Acute ocular pain therapies that are soon to be developed will benefit from advances in technology that address a number of problems with existing acute ocular pain treatments, including compliance and contact time with layers of ocular tissue. By 2025, many new competitors are anticipated to enter the market for acute ocular pain treatments, including OCS-01 (Oculis SA), SURF-201 (Surface Ophthalmics), APP13007 (Formosa Pharmaceuticals), SDN-037 (Visiox Pharma), DEXYCU (EyePoint Pharmaceuticals), and SVT-15473 (Salvat Laboratories). To stand out from the competition, major pharma companies that treat acute ocular pain use various drug delivery systems and platforms.

Pharma behemoths continue to be interested in the advantages of corticosteroids' anti-inflammatory effects. Nonetheless, corticosteroid side effects must be taken into consideration despite their potentially beneficial activity. Moreover, the present pipeline for treating acute ocular pain focuses mostly on pain associated with cataracts and eye procedures. As a result, the market for treating acute ocular pain urgently needs novel medicines that deal with various ocular ailments and overcome the drawbacks of corticosteroids.

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